Sfrp1 | secreted frizzled-related protein 1
Physiological systems
20 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Adipose tissue Vision/eye
18 No significant impact
4 Not tested
Data collections
Viability data
Body weight measurements
Embryo imaging data
Body weight measurements
Embryo imaging data
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal pupil morphology | 1 supporting dataset | Sfrp1tm1Aksh | homozygote | Early adult | 1.45x10-5 | ||
| increased total body fat amount | 1 supporting dataset | Sfrp1tm1Aksh | homozygote | Early adult | 5.6x10-5 | ||
| abnormal iris morphology | 1 supporting dataset | Sfrp1tm1Aksh | homozygote | Early adult | 4.01x10-5 |
| | | | | | | | | | |
Human diseases caused by Sfrp1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Sfrp1.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Sfrp1tm1(EGFP/cre/ERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Sfrp1tm1.1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | ES Cell |
| Sfrp1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Sfrp1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |