Cox5b | cytochrome c oxidase subunit 5B
GeneMGI:88475
Physiological systems
21 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Integument Limbs/digits/tail Vision/eye Liver/biliary system Behavior/neurological Mortality/aging
15 No significant impact
3 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:51Adult tissues
62Embryo tissues
| abnormal skin coloration | 1 supporting dataset | Cox5btm2b(EUCOMM)Hmgu | heterozygote | Early adult | 8.89x10-7 | ||
| unresponsive to tactile stimuli | 1 supporting dataset | Cox5btm2b(EUCOMM)Hmgu | heterozygote | E18.5 | N/A * | ||
| abnormal liver size | 1 supporting dataset | Cox5btm2b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * | ||
| pallor | 1 supporting dataset | Cox5btm2b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * | ||
| abnormal embryonic autopod plate morphology | 1 supporting dataset | Cox5btm2b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Cox5btm2b(EUCOMM)Hmgu | heterozygote | Early adult | 4.02x10-5 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Cox5btm2b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Cox5btm2b(EUCOMM)Hmgu | homozygote | E15.5 | N/A * | ||
| pale liver | 1 supporting dataset | Cox5btm2b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
Human diseases caused by Cox5b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Cox5b.
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| Cox5btm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Cox5btm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cox5btm2b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Cox5btm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |