Col1a2 | collagen, type I, alpha 2
Physiological systems
18 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system
7 No significant impact
6 Not tested
Data collections
Gene metrics:18Significant phenotypes
15Associated diseases
Expression examined in:49Adult tissues
42Embryo tissues
| increased heart weight | 1 supporting dataset | Col1a2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.5x10-8 | ||
| enlarged heart | 1 supporting dataset | Col1a2tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased bone mineral content | 1 supporting dataset | Col1a2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.04x10-7 | ||
| increased circulating alkaline phosphatase level | 2 supporting datasets | Col1a2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 6.23x10-16 | ||
| increased neutrophil cell number | 2 supporting datasets | Col1a2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.41x10-6 | ||
| increased bone mineral density | 1 supporting dataset | Col1a2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.49x10-6 | ||
| decreased grip strength | 4 supporting datasets | Col1a2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.36x10-10 | ||
| decreased total body fat amount | 1 supporting dataset | Col1a2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 8.95x10-5 | ||
| enlarged spleen | 1 supporting dataset | Col1a2tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased large unstained cell number | 2 supporting datasets | Col1a2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.25x10-7 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/4) | 0.7% (4/570) |
| aorta | heterozygote | Wholemount images | 100% (4/4) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | 100% (4/4) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (4/4) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (4/4) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/4) | 0% (0/588) |
| cartilage tissue | heterozygote | Wholemount images | 100% (4/4) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Wholemount images | 100% (4/4) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/4) | 0.41% (2/491) |
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Col1a2.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Col1a2em1H | Exon Deletion | | mouse |
| Col1a2em2H | Exon Deletion | | mouse |
| Col1a2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Col1a2tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Col1a2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |