Col4a5 | collagen, type IV, alpha 5

Physiological systems

17 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Renal/urinary system

10 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:27Significant phenotypes

4Associated diseases

Expression examined in:92Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal kidney morphology	1 supporting dataset	Col4a5^{tm1b(EUCOMM)Wtsi}	hemizygote	Early adult	N/A ^*
increased red blood cell distribution width	1 supporting dataset	Col4a5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.2x10^-21
increased leukocyte cell number	1 supporting dataset	Col4a5^{tm1b(EUCOMM)Wtsi}	hemizygote	Early adult	6.27x10^-5
increased circulating calcium level	1 supporting dataset	Col4a5^{tm1b(EUCOMM)Wtsi}	hemizygote	Early adult	6.81x10^-11
abnormal kidney morphology	1 supporting dataset	Col4a5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating amylase level	1 supporting dataset	Col4a5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	0
decreased total body fat amount	1 supporting dataset	Col4a5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.67x10^-7
decreased hemoglobin content	1 supporting dataset	Col4a5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.37x10^-58
decreased circulating total protein level	1 supporting dataset	Col4a5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	0
increased circulating cholesterol level	1 supporting dataset	Col4a5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.6x10^-12

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Col4a5.

Associated images

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Histopathology

There is no histopathology data found for Col4a5.

IMPC related publications

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External links

No external links available for Col4a5.

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*Col4a5^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Col4a5^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Col4a5^{tm40775(L1L2_st1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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