Col18a1 | collagen, type XVIII, alpha 1

GeneMGI:88451Synonyms: endostatin

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Nervous system Vision/eye Behavior/neurological Cardiovascular system

11 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

3Associated diseases

Expression examined in:48Adult tissues

50Embryo tissues

Phenotypes

Phy. System:



abnormal retina blood vessel morphology	2 supporting datasets	Col18a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.24x10^-15
hyperactivity	2 supporting datasets	Col18a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.87x10^-5
abnormal optic disk morphology	1 supporting dataset	Col18a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.2x10^-12
abnormal lens morphology	1 supporting dataset	Col18a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.27x10^-5
abnormal iris pigmentation	1 supporting dataset	Col18a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.14x10^-16
irregularly shaped pupil	1 supporting dataset	Col18a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	4.6x10^-8
abnormal retina morphology	1 supporting dataset	Col18a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	9.8x10^-5
abnormal retina vasculature morphology	1 supporting dataset	Col18a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.61x10^-17
decreased circulating glucose level	1 supporting dataset	Col18a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.94x10^-5
increased fasting circulating glucose level	1 supporting dataset	Col18a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.49x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Col18a1.

Associated images

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Histopathology

There is no histopathology data found for Col18a1.

IMPC related publications

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External links

No external links available for Col18a1.

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*Col18a1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell mouse
*Col18a1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Col18a1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Col18a1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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