Col11a1 | collagen, type XI, alpha 1
Physiological systems
21 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Growth/size/body region Limbs/digits/tail Digestive/alimentary Mortality/aging Craniofacial Cardiovascular system
15 No significant impact
3 Not tested
Data collections
Gene metrics:7Significant phenotypes
9Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal tail morphology | 1 supporting dataset | Col11a1em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Col11a1em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| abnormal facial morphology | 1 supporting dataset | Col11a1em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| abnormal limb morphology | 1 supporting dataset | Col11a1em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| protruding tongue | 1 supporting dataset | Col11a1em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| cleft palate | 1 supporting dataset | Col11a1em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| increased heart left ventricle size | 1 supporting dataset | Col11a1em1(IMPC)Bay | heterozygote | Early adult | 3.05x10-5 |
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Human diseases caused by Col11a1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Col11a1.
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| Col11a1em1(IMPC)Bay | Exon Deletion | | mouse |
| Col11a1em2(IMPC)Wtsi | Exon Deletion | | mouse |
| Col11a1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Col11a1tm44767(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Col11a1tm44767(L1L2_st1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |