Clcn1 | chloride channel, voltage-sensitive 1

GeneMGI:88417Synonyms: Clc1, nmf355, +3 more

Physiological systems

16 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Growth/size/body region Nervous system Vision/eye Hearing/vestibular/ear Hematopoietic system Behavior/neurological Cardiovascular system

6 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:27Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



tremors	1 supporting dataset	Clcn1^em1(IMPC)Mbp	homozygote	Early adult	2.33x10^-21
decreased body length	1 supporting dataset	Clcn1^em1(IMPC)Mbp	homozygote	Early adult	6.24x10^-32
decreased circulating glucose level	1 supporting dataset	Clcn1^em1(IMPC)Mbp	homozygote	Early adult	1.62x10^-5
decreased locomotor activity	9 supporting datasets	Clcn1^em1(IMPC)Mbp	homozygote	Early adult	1.25x10^-28
abnormal gait	1 supporting dataset	Clcn1^em1(IMPC)Mbp	homozygote	Early adult	2.05x10^-20
decreased vertical activity	1 supporting dataset	Clcn1^em1(IMPC)Mbp	homozygote	Early adult	2.21x10^-5
abnormal eye morphology	1 supporting dataset	Clcn1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased grip strength	3 supporting datasets	Clcn1^em1(IMPC)Mbp	homozygote	Early adult	6.85x10^-23
decreased prepulse inhibition	3 supporting datasets	Clcn1^em1(IMPC)Mbp	homozygote	Early adult	2.04x10^-10
abnormal cholesterol homeostasis	1 supporting dataset	Clcn1^em1(IMPC)Mbp	homozygote	Early adult	4.19x10^-18

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Clcn1.

Associated images

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Histopathology

There is no histopathology data found for Clcn1.

IMPC related publications

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External links

No external links available for Clcn1.

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*Clcn1^em1(IMPC)Mbp*	Inter-exon deletion	‌	mouse
*Clcn1^{tm115462(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Clcn1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Clcn1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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