Ckb | creatine kinase, brain
Physiological systems
21 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Immune system Integument Adipose tissue Growth/size/body region Nervous system Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton
12 No significant impact
3 Not tested
Data collections
Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| decreased exploration in new environment | 1 supporting dataset | Ckbtm1.1(KOMP)Wtsi | homozygote | Early adult | 2.62x10-5 | ||
| increased mean corpuscular volume | 1 supporting dataset | Ckbtm1.1(KOMP)Wtsi | homozygote | Early adult | 3.43x10-15 | ||
| increased lymphocyte cell number | 1 supporting dataset | Ckbtm1.1(KOMP)Wtsi | homozygote | Early adult | 8x10-5 | ||
| abnormal auditory brainstem response | 1 supporting dataset | Ckbtm1.1(KOMP)Wtsi | homozygote | Early adult | 3.27x10-5 | ||
| decreased brain weight | 1 supporting dataset | Ckbtm1.1(KOMP)Wtsi | homozygote | Early adult | 4.29x10-5 | ||
| decreased total body fat amount | 1 supporting dataset | Ckbtm1.1(KOMP)Wtsi | homozygote | Early adult | 1.32x10-6 | ||
| increased bone mineral content | 1 supporting dataset | Ckbtm1.1(KOMP)Wtsi | homozygote | Early adult | 4.42x10-8 | ||
| abnormal vibrissa morphology | 1 supporting dataset | Ckbtm1.1(KOMP)Wtsi | homozygote | Early adult | 1.15x10-7 | ||
| decreased prepulse inhibition | 1 supporting dataset | Ckbtm1.1(KOMP)Wtsi | homozygote | Early adult | 1.12x10-6 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Ckbtm1.1(KOMP)Wtsi | homozygote | Early adult | 1.77x10-9 |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 100% (1/1) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
External links
No external links available for Ckb.
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| Ckbtm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell mouse |
| Ckbtm1.1(KOMP)Wtsi | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Ckbtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ckbtm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |