Cd27 | CD27 antigen
Physiological systems
22 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Limbs/digits/tail Nervous system Hematopoietic system Cardiovascular system
14 No significant impact
2 Not tested
Data collections
Gene metrics:11Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal testis morphology | 1 supporting dataset | Cd27em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal seminal vesicle morphology | 1 supporting dataset | Cd27em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged heart | 1 supporting dataset | Cd27em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| decreased lean body mass | 1 supporting dataset | Cd27em1(IMPC)Ccpcz | homozygote | Early adult | 3.31x10-5 | ||
| abnormal heart morphology | 1 supporting dataset | Cd27em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | 1 supporting dataset | Cd27em1(IMPC)Ccpcz | homozygote | Early adult | 5.47x10-5 | ||
| small testis | 1 supporting dataset | Cd27em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal digit morphology | 1 supporting dataset | Cd27em1(IMPC)Ccpcz | homozygote | Early adult | 7.12x10-5 | ||
| increased prepulse inhibition | 1 supporting dataset | Cd27em1(IMPC)Ccpcz | homozygote | Early adult | 5.68x10-5 | ||
| small seminal vesicle | 1 supporting dataset | Cd27em1(IMPC)Ccpcz | homozygote | Early adult | N/A * |
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Human diseases caused by Cd27 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cd27.
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| Cd27em1(IMPC)Ccpcz | Intra-exon deletion | | mouse |
| Cd27tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Cd27tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Cd27tm379101(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |