Cbl | Casitas B-lineage lymphoma

GeneMGI:88279Synonyms: Cbl-2, c-Cbl, +1 more

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Mortality/aging Cardiovascular system

16 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:3Significant phenotypes
6Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, incomplete penetrance1 supporting datasetCbltm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
prolonged PR interval1 supporting datasetCbltm1b(EUCOMM)HmguheterozygoteEarly adult9.85x10-8 
thick ventricular wall1 supporting datasetCbltm1b(EUCOMM)HmguheterozygoteEarly adult3.29x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cbltm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Cbltm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Cbltm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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