Ctnnb1 | catenin beta 1

GeneMGI:88276Synonyms: catenin (cadherin associated protein), beta 1, beta-catenin, +2 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Growth/size/body region Behavior/neurological Skeleton Craniofacial

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:7Significant phenotypes
16Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal bone mineralization1 supporting datasetCtnnb1BfcheterozygoteEarly adult1.9x10-8 
increased bone mineral density1 supporting datasetCtnnb1BfcheterozygoteEarly adult1.07x10-13 
increased startle reflex3 supporting datasetsCtnnb1BfcheterozygoteEarly adult2.51x10-8 
abnormal cranium morphology1 supporting datasetCtnnb1BfcheterozygoteEarly adult7.65x10-6 
increased bone mineral content1 supporting datasetCtnnb1BfcheterozygoteEarly adult7.21x10-8 
abnormal startle reflex1 supporting datasetCtnnb1BfcheterozygoteEarly adult3.6x10-9 
abnormal head morphology1 supporting datasetCtnnb1BfcheterozygoteEarly adult9.73x10-11 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ctnnb1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Ctnnb1tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Ctnnb1tm39547(L1L2_gt0)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Ctnnb1tm39547(pL1L2_GT0_DelLacZ_bsd)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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