Anxa6 | annexin A6
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Growth/size/body region Vision/eye Skeleton
14 No significant impact
5 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased bone mineral content | 1 supporting dataset | Anxa6tm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.13x10-6 | ||
| decreased circulating cholesterol level | 1 supporting dataset | Anxa6tm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.62x10-5 | ||
| increased lean body mass | 1 supporting dataset | Anxa6tm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.11x10-5 | ||
| decreased circulating LDL cholesterol level | 1 supporting dataset | Anxa6tm1a(EUCOMM)Wtsi | homozygote | Early adult | 6.9x10-5 | ||
| abnormal eye size | 1 supporting dataset | Anxa6tm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.31x10-6 | ||
| abnormal vibrissa morphology | 1 supporting dataset | Anxa6tm1a(EUCOMM)Wtsi | homozygote | Early adult | 8.88x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | n/a | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/1) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Anxa6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Anxa6.
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| Anxa6tm1(NCOM)Cmhd | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Anxa6tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Anxa6tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Anxa6tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Anxa6tm350(pL1L2_GT0_bsd_frt15_neo_barcode) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |