Atp1a3 | ATPase, Na+/K+ transporting, alpha 3 polypeptide
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological Mortality/aging
16 No significant impact
5 Not tested
Gene metrics:6Significant phenotypes
8Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| improved glucose tolerance | 1 supporting dataset | Atp1a3tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.51x10-5 | ||
| decreased anxiety-related response | 1 supporting dataset | Atp1a3tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.38x10-7 | ||
| hyperactivity | 2 supporting datasets | Atp1a3tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.13x10-7 | ||
| abnormal locomotor behavior | 1 supporting dataset | Atp1a3tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.2x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Atp1a3tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased exploration in new environment | 1 supporting dataset | Atp1a3tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.62x10-5 |
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External links
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| Atp1a3em1H | Point Mutation | | mouse |
| Atp1a3tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Atp1a3tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |