Aprt | adenine phosphoribosyl transferase
GeneMGI:88061
Physiological systems
20 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Mortality/aging
17 No significant impact
4 Not tested
Data collections
Gene metrics:3Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal retina morphology | 1 supporting dataset | Aprtem1(IMPC)Hmgu | homozygote | Early adult | 9.53x10-7 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Aprtem1(IMPC)Hmgu | homozygote | Early adult | N/A * | ||
| increased respiratory quotient | 1 supporting dataset | Aprtem1(IMPC)Hmgu | heterozygote | Early adult | 4.94x10-5 |
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Human diseases caused by Aprt mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Aprt.
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| Aprtem1(IMPC)Hmgu | Exon Deletion | | mouse |
| Aprttm1(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |