App | amyloid beta precursor protein
Physiological systems
19 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Mortality/aging
11 No significant impact
5 Not tested
Data collections
Gene metrics:9Significant phenotypes
9Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased total retina thickness | 1 supporting dataset | Apptm1b(KOMP)Wtsi | heterozygote | Early adult | 6.34x10-8 | ||
| increased cornea thickness | 1 supporting dataset | Apptm1b(KOMP)Wtsi | heterozygote | Early adult | 2.92x10-7 | ||
| increased blood urea nitrogen level | 1 supporting dataset | Apptm1b(KOMP)Wtsi | heterozygote | Early adult | 5.41x10-7 | ||
| short tibia | 1 supporting dataset | Apptm1b(KOMP)Wtsi | heterozygote | Early adult | 8.89x10-5 | ||
| increased monocyte cell number | 1 supporting dataset | Apptm1b(KOMP)Wtsi | heterozygote | Late adult | 7.9x10-5 | ||
| increased circulating calcium level | 1 supporting dataset | Apptm1b(KOMP)Wtsi | heterozygote | Early adult | 3.17x10-5 | ||
| increased neutrophil cell number | 1 supporting dataset | Apptm1b(KOMP)Wtsi | heterozygote | Late adult | 4.81x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Apptm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| decreased grip strength | 1 supporting dataset | Apptm1b(KOMP)Wtsi | heterozygote | Early adult | 2.46x10-5 |
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Human diseases caused by App mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for App.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Appem4(IMPC)H | Exon Deletion | | mouse |
| Apptm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Apptm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |