App | amyloid beta precursor protein

GeneMGI:88059Synonyms: betaAPP, E030013M08Rik, +5 more

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Mortality/aging

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

9Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased total retina thickness	1 supporting dataset	App^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	6.34x10^-8
increased cornea thickness	1 supporting dataset	App^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.92x10^-7
increased blood urea nitrogen level	1 supporting dataset	App^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	5.41x10^-7
short tibia	1 supporting dataset	App^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	8.89x10^-5
increased monocyte cell number	1 supporting dataset	App^{tm1b(KOMP)Wtsi}	heterozygote	Late adult	7.9x10^-5
increased circulating calcium level	1 supporting dataset	App^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.17x10^-5
increased neutrophil cell number	1 supporting dataset	App^{tm1b(KOMP)Wtsi}	heterozygote	Late adult	4.81x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	App^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased grip strength	1 supporting dataset	App^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.46x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for App.

Associated images

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Histopathology

There is no histopathology data found for App.

IMPC related publications

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External links

No external links available for App.

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*App^em4(IMPC)H*	Exon Deletion	‌	mouse
*App^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*App^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

My Genes