App | amyloid beta precursor protein

GeneMGI:88059Synonyms: betaAPP, E030013M08Rik, +5 more

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Mortality/aging

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

9Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased total retina thickness	1 supporting dataset	App^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	6.34x10^-8
increased cornea thickness	1 supporting dataset	App^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.92x10^-7
increased blood urea nitrogen level	1 supporting dataset	App^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	5.41x10^-7
short tibia	1 supporting dataset	App^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	8.89x10^-5
increased monocyte cell number	1 supporting dataset	App^{tm1b(KOMP)Wtsi}	heterozygote	Late adult	7.9x10^-5
increased circulating calcium level	1 supporting dataset	App^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.17x10^-5
increased neutrophil cell number	1 supporting dataset	App^{tm1b(KOMP)Wtsi}	heterozygote	Late adult	4.81x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	App^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased grip strength	1 supporting dataset	App^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.46x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for App.

Associated images

Loading...

Histopathology

There is no histopathology data found for App.

IMPC related publications

Loading...

External links

No external links available for App.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*App^em4(IMPC)H*	Exon Deletion	‌	mouse
*App^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*App^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

My Genes