Amelx | amelogenin, X-linked
Physiological systems
22 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Digestive/alimentary Respiratory system Hematopoietic system Skeleton Craniofacial Cardiovascular system
11 No significant impact
2 Not tested
Data collections
Gene metrics:24Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal thymus morphology | 1 supporting dataset | Amelxem1(IMPC)Ccpcz | hemizygote | Early adult | N/A * | ||
| enlarged lymph nodes | 1 supporting dataset | Amelxem1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| enlarged thymus | 1 supporting dataset | Amelxem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged stomach | 1 supporting dataset | Amelxem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| vertebral transformation | 1 supporting dataset | Amelxem1(IMPC)Ccpcz | heterozygote | Early adult | 1.55x10-6 | ||
| abnormal tooth morphology | 3 supporting datasets | Amelxem1(IMPC)Ccpcz | hemizygote | Early adult | N/A * | ||
| abnormal testis morphology | 1 supporting dataset | Amelxem1(IMPC)Ccpcz | hemizygote | Early adult | N/A * | ||
| abnormal tooth morphology | 2 supporting datasets | Amelxem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| small spleen | 1 supporting dataset | Amelxem1(IMPC)Ccpcz | hemizygote | Early adult | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Amelxem1(IMPC)Ccpcz | hemizygote | Early adult | N/A * |
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Human diseases caused by Amelx mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Amelx.
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| Amelxem1(IMPC)Ccpcz | Intra-exon deletion | | mouse |
| Amelxtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Amelxtm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |