Aldoa | aldolase A, fructose-bisphosphate
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Vision/eye Hematopoietic system Behavior/neurological Mortality/aging
15 No significant impact
4 Not tested
Data collections
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:51Adult tissues
62Embryo tissues
| decreased leukocyte cell number | 1 supporting dataset | Aldoatm1.1(KOMP)Wtsi | heterozygote | Early adult | 1.84x10-8 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Aldoatm1.1(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| decreased thigmotaxis | 1 supporting dataset | Aldoatm1.1(KOMP)Wtsi | heterozygote | Early adult | 2.72x10-5 | ||
| decreased total retina thickness | 1 supporting dataset | Aldoatm1.1(KOMP)Wtsi | heterozygote | Early adult | 3.3x10-5 |
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| adrenal gland | heterozygote | Wholemount images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Wholemount images | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Wholemount images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Wholemount images | 100% (2/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 100% (1/1) | 7.75% (22/284) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Aldoa mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Aldoa.
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| Aldoatm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Aldoatm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell mouse |
| Aldoatm1.1(KOMP)Wtsi | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |