Adra2a | adrenergic receptor, alpha 2a

GeneMGI:87934Synonyms: alpha2A-AR, alpha(2A)AR, +4 more

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Nervous system Behavior/neurological

16 No significant impact

3 Not tested

Gene metrics:7Significant phenotypes
1Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

decreased prepulse inhibition1 supporting datasetAdra2atm1.1(KOMP)VlcghomozygoteEarly adult3.79x10-5 
small testis1 supporting datasetAdra2atm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
improved glucose tolerance2 supporting datasetsAdra2atm1.1(KOMP)VlcghomozygoteEarly adult1.63x10-8 
hyperactivity4 supporting datasetsAdra2atm1.1(KOMP)VlcghomozygoteEarly adult2.66x10-5 
decreased fasting circulating glucose level1 supporting datasetAdra2atm1.1(KOMP)VlcghomozygoteEarly adult7.5x10-9 
decreased startle reflex1 supporting datasetAdra2atm1.1(KOMP)VlcghomozygoteEarly adult2.5x10-5 
abnormal testis morphology1 supporting datasetAdra2atm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Adra2atm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Adra2atm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse

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