Cpgi5563 | CpG island 5563

GeneMGI:5670665Synonyms: CGI5563

Physiological systems

16 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Adipose tissue Growth/size/body region Mortality/aging

12 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:17Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, incomplete penetrance1 supporting datasetCpgi5563tm1.1(NCC)WCShomozygoteEarly adultN/A * 
increased lean body mass1 supporting datasetCpgi5563tm1.1(NCC)WCShomozygoteEarly adult1.57x10-7 
increased circulating chloride level1 supporting datasetCpgi5563tm1.1(NCC)WCShomozygoteEarly adult2.51x10-5 
decreased circulating triglyceride level1 supporting datasetCpgi5563tm1.1(NCC)WCShomozygoteEarly adult7.46x10-10 
decreased circulating glucose level1 supporting datasetCpgi5563tm1.1(NCC)WCShomozygoteEarly adult4.47x10-5 
decreased circulating cholesterol level1 supporting datasetCpgi5563tm1.1(NCC)WCShomozygoteEarly adult6.44x10-15 
decreased fasting circulating glucose level1 supporting datasetCpgi5563tm1.1(NCC)WCShomozygoteEarly adult1.3x10-6 
decreased circulating glycerol level1 supporting datasetCpgi5563tm1.1(NCC)WCShomozygoteEarly adult1.54x10-9 
decreased circulating LDL cholesterol level1 supporting datasetCpgi5563tm1.1(NCC)WCShomozygoteEarly adult2.86x10-7 
increased circulating magnesium level1 supporting datasetCpgi5563tm1.1(NCC)WCShomozygoteEarly adult5.46x10-8 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

Human diseases caused by Cpgi5563 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Cpgi5563tm1(NCC)WCSReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Cpgi5563tm1(NCC)WCSKO first allele (reporter-tagged insertion with conditional potential)targeting vector
Cpgi5563tm1.1(NCC)WCSReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Cpgi5563tm1000451(L1L2_lncRNA_xpA3_BactNeo)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Cpgi5563tm1000462(L1L2_lncRNA_xpA3_BactNeo)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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