Cfap47 | cilia and flagella associated protein 47

GeneMGI:3781475Synonyms: Gm8787, Gm7173, +3 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Immune system Adipose tissue Growth/size/body region Vision/eye Hematopoietic system

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal eyelid morphology1 supporting datasetCfap47em1(IMPC)HmguhemizygoteEarly adult5.19x10-8 
increased total body fat amount2 supporting datasetsCfap47em1(IMPC)HmguhomozygoteEarly adult1.39x10-7 
decreased spleen weight1 supporting datasetCfap47em1(IMPC)HmguhomozygoteEarly adult1.92x10-5 
decreased lean body mass2 supporting datasetsCfap47em1(IMPC)HmguhomozygoteEarly adult5.79x10-10 
abnormal eyelid morphology1 supporting datasetCfap47em1(IMPC)HmguhomozygoteEarly adult2.46x10-10 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

Human diseases caused by Cfap47 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Cfap47em1(IMPC)HmguExon Deletionmouse
Cfap47tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Cfap47tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Cfap47tm296533(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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