Hectd4 | HECT domain E3 ubiquitin protein ligase 4

GeneMGI:3647820Synonyms: Gm15800

Physiological systems

16 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Vision/eye Hematopoietic system

12 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal retina morphology	1 supporting dataset	Hectd4^{em1(IMPC)Marc}	heterozygote	Early adult	2.47x10^-6
increased eosinophil cell number	2 supporting datasets	Hectd4^{em1(IMPC)Marc}	heterozygote	Early adult	1.68x10^-23
decreased circulating glucose level	1 supporting dataset	Hectd4^{em1(IMPC)Marc}	heterozygote	Early adult	1.35x10^-6
increased basophil cell number	2 supporting datasets	Hectd4^{em1(IMPC)Marc}	heterozygote	Early adult	5.02x10^-60
increased circulating alanine transaminase level	1 supporting dataset	Hectd4^{em1(IMPC)Marc}	heterozygote	Early adult	4.1x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hectd4.

Associated images

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Histopathology

There is no histopathology data found for Hectd4.

IMPC related publications

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External links

No external links available for Hectd4.

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*Hectd4^{em1(IMPC)Marc}*	Deletion	‌	mouse
*Hectd4^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Hectd4^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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