Insyn2b | inhibitory synaptic factor family member 2B

GeneMGI:3643491Synonyms: Fam196b, Gm6041

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Behavior/neurological

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



hyperactivity	6 supporting datasets	Insyn2b^em1(IMPC)J	homozygote	Early adult	3.83x10^-8
increased circulating alanine transaminase level	1 supporting dataset	Insyn2b^em1(IMPC)J	homozygote	Early adult	1.98x10^-5
increased leukocyte cell number	1 supporting dataset	Insyn2b^em1(IMPC)J	homozygote	Early adult	1.26x10^-5
decreased circulating phosphate level	1 supporting dataset	Insyn2b^em1(IMPC)J	homozygote	Early adult	2.44x10^-5
increased circulating glucose level	1 supporting dataset	Insyn2b^em1(IMPC)J	homozygote	Early adult	1.24x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Insyn2b.

Associated images

Download files

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

3 images

Combined SHIRPA and Dysmorphology

Images

Download files

Electrocardiogram (ECG)

Waveform Image

1 images

Eye Morphology

Images Ophthalmoscopy

6 images

X-ray

XRay Images Forepaw

6 images

X-ray

XRay Images Skull Dorso Ventral Orientation

6 images

X-ray

XRay Images Skull Lateral Orientation

6 images

X-ray

XRay Images Whole Body Dorso Ventral

6 images

X-ray

XRay Images Whole Body Lateral Orientation

Human diseases caused by Insyn2b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.



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Histopathology

There is no histopathology data found for Insyn2b.

IMPC related publications

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External links

No external links available for Insyn2b.

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*Insyn2b^em1(IMPC)J*	Intra-exon deletion	‌	mouse
*Insyn2b^{em1(IMPC)Wtsi}*	Deletion	‌	mouse

My Genes

Insyn2b | inhibitory synaptic factor family member 2B

Physiological systems

4 Significantly impacted by the knock-out

13 No significant impact

7 Not tested

Data collections

Phenotypes

lacZ Expression

Associated images

Auditory Brain Stem Response

Combined SHIRPA and Dysmorphology

Electrocardiogram (ECG)

Eye Morphology

X-ray

X-ray

X-ray

X-ray

X-ray

Human diseases caused by Insyn2b mutations

Histopathology

IMPC related publications

External links

Order Mouse and ES Cells

The IMPC Newsletter

Access Data Release 22.1 Data