Tmem145 | transmembrane protein 145
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Hearing/vestibular/ear Nervous system Vision/eye Behavior/neurological Cardiovascular system Renal/urinary system
13 No significant impact
4 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal auditory brainstem response | 6 supporting datasets | Tmem145em1(IMPC)Mbp | homozygote | Early adult | 1.83x10-6 | ||
| eye hemorrhage | 1 supporting dataset | Tmem145em1(IMPC)Mbp | homozygote | Early adult | 2.1x10-5 | ||
| cataract | 1 supporting dataset | Tmem145em1(IMPC)Mbp | homozygote | Early adult | 6.35x10-5 | ||
| decreased startle reflex | 1 supporting dataset | Tmem145em1(IMPC)Mbp | homozygote | Early adult | 1.13x10-5 | ||
| abnormal kidney morphology | 1 supporting dataset | Tmem145em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Tmem145em1(IMPC)Mbp | homozygote | Early adult | 1.96x10-7 | ||
| abnormal vitreous body morphology | 1 supporting dataset | Tmem145em1(IMPC)Mbp | homozygote | Early adult | 5.99x10-5 | ||
| abnormal retina morphology | 1 supporting dataset | Tmem145em1(IMPC)Mbp | homozygote | Early adult | 5.3x10-5 | ||
| decreased prepulse inhibition | 1 supporting dataset | Tmem145em1(IMPC)Mbp | homozygote | Early adult | 1.42x10-6 | ||
| small kidney | 1 supporting dataset | Tmem145em1(IMPC)Mbp | homozygote | Early adult | N/A * |
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Human diseases caused by Tmem145 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tmem145.
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| Tmem145em1(IMPC)Mbp | Intra-exon deletion | | mouse |
| Tmem145tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Tmem145tm459065(L1L2_GT0_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |