Mdc1 | mediator of DNA damage checkpoint 1

GeneMGI:3525201Synonyms: NFBD1

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Reproductive system Behavior/neurological Cardiovascular system

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



decreased cardiac stroke volume	1 supporting dataset	Mdc1^em1(IMPC)Bay	homozygote	Late adult	4.82x10^-6
decreased cardiac output	1 supporting dataset	Mdc1^em1(IMPC)Bay	homozygote	Late adult	1.59x10^-5
decreased locomotor activity	1 supporting dataset	Mdc1^em1(IMPC)Bay	homozygote	Late adult	6.88x10^-5
male infertility	1 supporting dataset	Mdc1^em1(IMPC)Bay	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mdc1.

Associated images

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Histopathology

There is no histopathology data found for Mdc1.

IMPC related publications

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External links

No external links available for Mdc1.

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*Mdc1^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Mdc1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Mdc1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

My Genes