Trpa1 | transient receptor potential cation channel, subfamily A, member 1
Physiological systems
17 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Adipose tissue Growth/size/body region Vision/eye Behavior/neurological
13 No significant impact
7 Not tested
Data collections
Gene metrics:4Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal vocalization | 1 supporting dataset | Trpa1em1(IMPC)J | homozygote | Early adult | 1.04x10-6 | ||
| increased total body fat amount | 1 supporting dataset | Trpa1em1(IMPC)J | homozygote | Early adult | 1.4x10-5 | ||
| abnormal cornea morphology | 1 supporting dataset | Trpa1em1(IMPC)J | homozygote | Early adult | 2.79x10-5 | ||
| decreased lean body mass | 1 supporting dataset | Trpa1em1(IMPC)J | homozygote | Early adult | 1.18x10-5 |
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Human diseases caused by Trpa1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Trpa1.
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| Trpa1em1(IMPC)J | Exon Deletion | | mouse |
| Trpa1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Trpa1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Trpa1tm2(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |