Awat2 | acyl-CoA wax alcohol acyltransferase 2
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Endocrine/exocrine gland Vision/eye Cardiovascular system Renal/urinary system
14 No significant impact
4 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal eye morphology | 1 supporting dataset | Awat2em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal eye morphology | 1 supporting dataset | Awat2em1(IMPC)Mbp | hemizygote | Early adult | N/A * | ||
| abnormal urinary bladder morphology | 1 supporting dataset | Awat2em1(IMPC)Mbp | hemizygote | Early adult | N/A * | ||
| abnormal pancreas morphology | 1 supporting dataset | Awat2em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| eye hemorrhage | 1 supporting dataset | Awat2em1(IMPC)Mbp | hemizygote | Early adult | 5.31x10-12 | ||
| abnormal eyelid morphology | 1 supporting dataset | Awat2em1(IMPC)Mbp | hemizygote | Early adult | 3.28x10-21 | ||
| abnormal lymph node morphology | 1 supporting dataset | Awat2em1(IMPC)Mbp | hemizygote | Early adult | N/A * | ||
| eye hemorrhage | 1 supporting dataset | Awat2em1(IMPC)Mbp | homozygote | Early adult | 2.32x10-13 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Awat2em1(IMPC)Mbp | homozygote | Early adult | 9.61x10-8 | ||
| abnormal eyelid morphology | 1 supporting dataset | Awat2em1(IMPC)Mbp | homozygote | Early adult | 3.67x10-21 |
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Human diseases caused by Awat2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Awat2.
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| Awat2em1(IMPC)Mbp | Exon Deletion | | mouse |
| Awat2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Awat2tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Awat2tm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |