Dgat2l6 | diacylglycerol O-acyltransferase 2-like 6
Physiological systems
21 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Growth/size/body region Cardiovascular system Renal/urinary system
16 No significant impact
3 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:146Adult tissues
0Embryo tissues
| abnormal kidney morphology | 1 supporting dataset | Dgat2l6tm1b(KOMP)Wtsi | hemizygote | Early adult | N/A * | ||
| enlarged heart | 1 supporting dataset | Dgat2l6tm1b(KOMP)Wtsi | hemizygote | Early adult | N/A * | ||
| absent vibrissae | 1 supporting dataset | Dgat2l6tm1b(KOMP)Wtsi | homozygote | Early adult | 7.48x10-5 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Dgat2l6tm1b(KOMP)Wtsi | homozygote | Early adult | 4.45x10-8 | ||
| abnormal heart morphology | 1 supporting dataset | Dgat2l6tm1b(KOMP)Wtsi | hemizygote | Early adult | N/A * | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Dgat2l6tm1b(KOMP)Wtsi | homozygote | Early adult | 1.45x10-6 |
| ‌ | ‌ | ‌ | ‌ | ‌ | ‌ | ‌ | ‌ | ‌ | ‌ |
| adrenal gland | hemizygote | n/a | 0% (0/1) | 0.7% (4/570) |
| adrenal gland | heterozygote | n/a | 0% (0/1) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/1) | 0.19% (1/533) |
| aorta | hemizygote | n/a | 0% (0/1) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/1) | 0% (0/17) |
| blood | hemizygote | n/a | 0% (0/1) | 0% (0/17) |
| bone marrow | hemizygote | n/a | 0% (0/1) | 0% (0/22) |
| bone marrow | heterozygote | n/a | 0% (0/1) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/1) | 0.86% (5/579) |
| brain | hemizygote | n/a | 0% (0/1) | 0.86% (5/579) |
Human diseases caused by Dgat2l6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dgat2l6.
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| Dgat2l6tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | ‌ | targeting vector ES Cell mouse |
| Dgat2l6tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | ‌ | mouse |
| Dgat2l6tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | ‌ | targeting vector ES Cell |