Traf7 | TNF receptor-associated factor 7
Physiological systems
20 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Immune system Vision/eye Mortality/aging
17 No significant impact
4 Not tested
Data collections
Gene metrics:7Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| cataract | 1 supporting dataset | Traf7em1(IMPC)Tcp | heterozygote | Early adult | 7.25x10-7 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Traf7em1(IMPC)Tcp | homozygote | E12.5 | N/A * | ||
| abnormal retina morphology | 1 supporting dataset | Traf7em1(IMPC)Tcp | heterozygote | Early adult | 1.13x10-5 | ||
| enlarged lymph nodes | 1 supporting dataset | Traf7em1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Traf7em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Traf7em1(IMPC)Tcp | homozygote | E15.5 | N/A * | ||
| abnormal lens morphology | 1 supporting dataset | Traf7em1(IMPC)Tcp | heterozygote | Early adult | 3.03x10-5 |
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Human diseases caused by Traf7 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Traf7.
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| Traf7em1(IMPC)Tcp | Exon Deletion | | mouse |
| Traf7tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Traf7tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |