Adgrd1 | adhesion G protein-coupled receptor D1
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Reproductive system Immune system Skeleton
15 No significant impact
6 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| female infertility | 1 supporting dataset | Adgrd1tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased anti-nuclear antigen antibody level | 4 supporting datasets | Adgrd1tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased bone mineral density | 1 supporting dataset | Adgrd1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.16x10-5 | ||
| decreased bone mineral content | 1 supporting dataset | Adgrd1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.61x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
Human diseases caused by Adgrd1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Adgrd1.
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| Adgrd1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Adgrd1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Adgrd1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Adgrd1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Adgrd1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Adgrd1tm45840(L1L2_st1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |