Zfp595 | zinc finger protein 595
Physiological systems
16 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Hematopoietic system
13 No significant impact
8 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
| decreased lymphocyte cell number | 1 supporting dataset | Zfp595tm1b(KOMP)Wtsi | homozygote | Early adult | 8.97x10-8 | ||
| decreased circulating glucose level | 1 supporting dataset | Zfp595tm1b(KOMP)Wtsi | homozygote | Early adult | 7.54x10-7 | ||
| decreased eosinophil cell number | 1 supporting dataset | Zfp595tm1b(KOMP)Wtsi | homozygote | Early adult | 4.04x10-5 | ||
| decreased leukocyte cell number | 1 supporting dataset | Zfp595tm1b(KOMP)Wtsi | homozygote | Early adult | 1.3x10-7 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Zfp595 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Zfp595.
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| Zfp595tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Zfp595tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Zfp595tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |