Timd6 | T cell immunoglobulin and mucin domain containing 6
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging
14 No significant impact
5 Not tested
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| trunk curl | 1 supporting dataset | Timd6tm1b(KOMP)Wtsi | heterozygote | Early adult | 5.31x10-13 | ||
| decreased lymphocyte cell number | 1 supporting dataset | Timd6tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.56x10-5 | ||
| increased neutrophil cell number | 1 supporting dataset | Timd6tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.45x10-6 | ||
| increased spleen weight | 1 supporting dataset | Timd6tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.16x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Timd6tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Timd6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Timd6.
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| Timd6tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Timd6tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Timd6tm37731(L1L2_st0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |