Cldn19 | claudin 19
GeneMGI:3033992
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Behavior/neurological Cardiovascular system
14 No significant impact
6 Not tested
Data collections
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:49Adult tissues
51Embryo tissues
| abnormal sleep behavior | 1 supporting dataset | Cldn19tm1.1(KOMP)Vlcg | homozygote | Early adult | 3.9x10-6 | ||
| shortened ST segment | 1 supporting dataset | Cldn19tm1.1(KOMP)Vlcg | homozygote | Early adult | 9.54x10-5 | ||
| shortened PR interval | 1 supporting dataset | Cldn19tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.81x10-6 | ||
| increased circulating sodium level | 1 supporting dataset | Cldn19tm1.1(KOMP)Vlcg | homozygote | Early adult | 3.86x10-6 | ||
| increased heart weight | 1 supporting dataset | Cldn19tm1.1(KOMP)Vlcg | homozygote | Early adult | 7.13x10-6 | ||
| decreased circulating free fatty acids level | 1 supporting dataset | Cldn19tm1.1(KOMP)Vlcg | homozygote | Early adult | 8.6x10-7 | ||
| shortened PQ interval | 1 supporting dataset | Cldn19tm1.1(KOMP)Vlcg | homozygote | Early adult | 3.21x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/1) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
External links
No external links available for Cldn19.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Cldn19tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Cldn19tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Cldn19tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Cldn19tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |