Kash5 | KASH domain containing 5
Physiological systems
17 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton
9 No significant impact
7 Not tested
Data collections
Gene metrics:10Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased lean body mass | 2 supporting datasets | Kash5em1(IMPC)J | homozygote | Early adult | 1.58x10-11 | ||
| abnormal bone structure | 1 supporting dataset | Kash5em1(IMPC)J | homozygote | Early adult | 6.18x10-11 | ||
| increased total body fat amount | 2 supporting datasets | Kash5em1(IMPC)J | homozygote | Early adult | 1.23x10-12 | ||
| female infertility | 1 supporting dataset | Kash5em1(IMPC)J | homozygote | Early adult | N/A * | ||
| increased leukocyte cell number | 1 supporting dataset | Kash5em1(IMPC)J | homozygote | Early adult | 2.55x10-6 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Kash5em1(IMPC)J | homozygote | Early adult | 1.72x10-5 | ||
| decreased locomotor activity | 1 supporting dataset | Kash5em1(IMPC)J | homozygote | Early adult | 8.65x10-6 | ||
| decreased bone mineral content | 2 supporting datasets | Kash5em1(IMPC)J | homozygote | Early adult | 4.95x10-21 | ||
| decreased bone mineral density | 1 supporting dataset | Kash5em1(IMPC)J | homozygote | Early adult | 2.47x10-16 | ||
| male infertility | 1 supporting dataset | Kash5em1(IMPC)J | homozygote | Early adult | N/A * |
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Human diseases caused by Kash5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Kash5.
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| Kash5em1(IMPC)J | Exon Deletion | | mouse |
| Kash5tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Kash5tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |