Pfkfb4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
GeneMGI:2687284
Physiological systems
22 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Reproductive system Vision/eye Behavior/neurological Cardiovascular system
18 No significant impact
2 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:146Adult tissues
0Embryo tissues
| abnormal vocalization | 1 supporting dataset | Pfkfb4tm1b(KOMP)Wtsi | homozygote | Early adult | 2.82x10-6 | ||
| eye hemorrhage | 1 supporting dataset | Pfkfb4tm1b(KOMP)Wtsi | homozygote | Early adult | 3.11x10-7 | ||
| female infertility | 1 supporting dataset | Pfkfb4tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | homozygote | Section images | 0% (0/1) | 0.7% (4/570) |
| adrenal gland | heterozygote | Section images Wholemount images | 100% (3/3) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| aorta | homozygote | n/a | 0% (0/1) | 0.19% (1/533) |
| blood | homozygote | n/a | 0% (0/1) | 0% (0/17) |
| blood | heterozygote | n/a | 0% (0/1) | 0% (0/17) |
| bone marrow | heterozygote | n/a | n/a | 0% (0/22) |
| bone marrow | homozygote | n/a | 0% (0/1) | 0% (0/22) |
| brain | heterozygote | Wholemount images | 100% (3/3) | 0.86% (5/579) |
| brain | homozygote | n/a | 100% (1/1) | 0.86% (5/579) |
Human diseases caused by Pfkfb4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Pfkfb4.
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| Pfkfb4tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Pfkfb4tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Pfkfb4tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |