Klhl29 | kelch-like 29
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Muscle Hematopoietic system Cardiovascular system Mortality/aging
13 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased respiratory quotient | 1 supporting dataset | Klhl29tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.82x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Klhl29tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased cardiac muscle contractility | 1 supporting dataset | Klhl29tm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.26x10-5 | ||
| increased heart rate | 1 supporting dataset | Klhl29tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.91x10-8 | ||
| prolonged QT interval | 1 supporting dataset | Klhl29tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 4.12x10-5 | ||
| increased large unstained cell number | 2 supporting datasets | Klhl29tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.43x10-8 | ||
| prolonged ST segment | 1 supporting dataset | Klhl29tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.45x10-6 |
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Human diseases caused by Klhl29 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Klhl29.
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| Klhl29tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Klhl29tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Klhl29tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Klhl29tm79707(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |