Aars2 | alanyl-tRNA synthetase 2, mitochondrial
Physiological systems
18 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Immune system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging
12 No significant impact
6 Not tested
Data collections
Gene metrics:8Significant phenotypes
5Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased basophil cell number | 2 supporting datasets | Aars2tm1(KOMP)Wtsi | heterozygote | Early adult | 2.05x10-7 | ||
| increased eosinophil cell number | 2 supporting datasets | Aars2tm1(KOMP)Wtsi | heterozygote | Early adult | 2.54x10-14 | ||
| abnormal heart left ventricle morphology | 1 supporting dataset | Aars2tm1(KOMP)Wtsi | heterozygote | Early adult | 3.79x10-7 | ||
| increased neutrophil cell number | 1 supporting dataset | Aars2tm1(KOMP)Wtsi | heterozygote | Early adult | 1.87x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Aars2tm1(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| decreased red blood cell distribution width | 1 supporting dataset | Aars2tm1(KOMP)Wtsi | heterozygote | Early adult | 9.38x10-6 | ||
| abnormal vocalization | 1 supporting dataset | Aars2tm1(KOMP)Wtsi | heterozygote | Early adult | 1.2x10-5 | ||
| impaired pupillary reflex | 1 supporting dataset | Aars2tm1(KOMP)Wtsi | heterozygote | Early adult | 7.74x10-5 |
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Human diseases caused by Aars2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Aars2.
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| Aars2tm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell mouse |