Mib2 | mindbomb E3 ubiquitin protein ligase 2
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Nervous system Vision/eye Behavior/neurological
15 No significant impact
4 Not tested
Data collections
Viability data
Body weight measurements
Embryo imaging data
Body weight measurements
Embryo imaging data
Gene metrics:8Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased grip strength | 2 supporting datasets | Mib2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 8.49x10-6 | ||
| abnormal retina morphology | 4 supporting datasets | Mib2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.03x10-5 | ||
| decreased lean body mass | 1 supporting dataset | Mib2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 7.06x10-5 | ||
| abnormal eye morphology | 1 supporting dataset | Mib2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.87x10-5 | ||
| decreased blood urea nitrogen level | 1 supporting dataset | Mib2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 8.47x10-5 | ||
| decreased prepulse inhibition | 1 supporting dataset | Mib2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.63x10-5 | ||
| abnormal tail movements | 1 supporting dataset | Mib2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 7.06x10-7 | ||
| decreased circulating amylase level | 1 supporting dataset | Mib2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.47x10-6 |
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Human diseases caused by Mib2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mib2.
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| Mib2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Mib2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Mib2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Mib2tm44581(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |