Ctdsp1 | CTD small phosphatase 1
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Behavior/neurological Craniofacial
15 No significant impact
5 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| decreased grip strength | 4 supporting datasets | Ctdsp1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.24x10-9 | ||
| hyperactivity | 2 supporting datasets | Ctdsp1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 7.07x10-6 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Ctdsp1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 6.23x10-7 | ||
| abnormal snout morphology | 1 supporting dataset | Ctdsp1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 9.67x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Ctdsp1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ctdsp1.
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| Ctdsp1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ctdsp1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ctdsp1tm45037(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |