Sox21 | SRY (sex determining region Y)-box 21
Physiological systems
19 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Integument Adipose tissue Growth/size/body region Nervous system Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Renal/urinary system
8 No significant impact
5 Not tested
Data collections
Gene metrics:28Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal coat/ hair morphology | 3 supporting datasets | Sox21em1(IMPC)Mbp | homozygote | Early adult | 3.97x10-16 | ||
| abnormal skin morphology | 2 supporting datasets | Sox21em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| decreased grip strength | 2 supporting datasets | Sox21em1(IMPC)Mbp | homozygote | Early adult | 3.63x10-7 | ||
| abnormal lymph node morphology | 2 supporting datasets | Sox21em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| decreased circulating cholesterol level | 1 supporting dataset | Sox21em1(IMPC)Mbp | homozygote | Early adult | 7.88x10-9 | ||
| increased neutrophil cell number | 1 supporting dataset | Sox21em1(IMPC)Mbp | homozygote | Early adult | 4.37x10-6 | ||
| enlarged lymph nodes | 2 supporting datasets | Sox21em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| increased monocyte cell number | 2 supporting datasets | Sox21em1(IMPC)Mbp | homozygote | Early adult | 4.17x10-8 | ||
| decreased locomotor activity | 2 supporting datasets | Sox21em1(IMPC)Mbp | homozygote | Early adult | 1.33x10-12 | ||
| increased mean corpuscular volume | 1 supporting dataset | Sox21em1(IMPC)Mbp | homozygote | Early adult | 1.47x10-5 |
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Human diseases caused by Sox21 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Sox21.
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| Sox21em1(IMPC)Mbp | Whole-gene deletion | | mouse |
| Sox21tm464323(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |