Prss53 | serine protease 53
Physiological systems
18 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Integument Growth/size/body region Hematopoietic system Behavior/neurological
12 No significant impact
6 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased circulating total protein level | 1 supporting dataset | Prss53em3(IMPC)Wtsi | homozygote | Early adult | 9.45x10-6 | ||
| increased circulating creatinine level | 1 supporting dataset | Prss53em3(IMPC)Wtsi | homozygote | Early adult | 4.1x10-5 | ||
| abnormal hair growth | 2 supporting datasets | Prss53em2(IMPC)Wtsi | homozygote | Early adult | 1.8x10-6 | ||
| absent pinna reflex | 1 supporting dataset | Prss53em2(IMPC)Wtsi | homozygote | Early adult | 7.78x10-7 | ||
| decreased leukocyte cell number | 1 supporting dataset | Prss53em3(IMPC)Wtsi | homozygote | Early adult | 3.82x10-5 | ||
| increased body length | 1 supporting dataset | Prss53em3(IMPC)Wtsi | homozygote | Early adult | 1.75x10-5 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Prss53em3(IMPC)Wtsi | homozygote | Early adult | 3.74x10-5 | ||
| abnormal vibrissa morphology | 1 supporting dataset | Prss53em1(IMPC)Wtsi | homozygote | Early adult | 8.65x10-17 |
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Human diseases caused by Prss53 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Prss53.
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| Prss53em1(IMPC)Wtsi | Exon Deletion | | mouse |
| Prss53em2(IMPC)Wtsi | Point Mutation | | mouse |
| Prss53em3(IMPC)Wtsi | Point Mutation | | mouse |
| Prss53tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Prss53tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Prss53tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Prss53tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |