Unc80 | unc-80, NALCN activator
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Behavior/neurological Mortality/aging Cardiovascular system
13 No significant impact
4 Not tested
Data collections
Gene metrics:9Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased body length | 1 supporting dataset | Unc80em1(IMPC)Tcp | heterozygote | Early adult | 2.94x10-5 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Unc80em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| decreased exploration in new environment | 1 supporting dataset | Unc80em1(IMPC)Tcp | heterozygote | Early adult | 1.77x10-13 | ||
| abnormal retina morphology | 1 supporting dataset | Unc80em1(IMPC)Tcp | heterozygote | Early adult | 1.44x10-5 | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Unc80em1(IMPC)Tcp | heterozygote | Early adult | 1.93x10-5 | ||
| decreased circulating sodium level | 1 supporting dataset | Unc80em1(IMPC)Tcp | heterozygote | Early adult | 6.03x10-8 | ||
| enlarged lymph nodes | 1 supporting dataset | Unc80em1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Unc80em1(IMPC)Tcp | heterozygote | Early adult | 1.68x10-5 | ||
| decreased circulating chloride level | 1 supporting dataset | Unc80em1(IMPC)Tcp | heterozygote | Early adult | 1.09x10-7 |
| | | | | | | | | | |
Human diseases caused by Unc80 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Unc80.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Unc80em1(IMPC)Tcp | Exon Deletion | | mouse |
| Unc80tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Unc80tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |