Atg4c | autophagy related 4C, cysteine peptidase

GeneMGI:2651854Synonyms: Apg4-C, autophagin 3, +2 more

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Immune system Growth/size/body region Hematopoietic system Skeleton Cardiovascular system

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased neutrophil cell number	2 supporting datasets	Atg4c^{em2(IMPC)Marc}	homozygote	Early adult	6.26x10^-11
increased eosinophil cell number	2 supporting datasets	Atg4c^{em2(IMPC)Marc}	homozygote	Early adult	3.49x10^-18
increased basophil cell number	2 supporting datasets	Atg4c^{em2(IMPC)Marc}	homozygote	Early adult	5.29x10^-18
decreased lymphocyte cell number	1 supporting dataset	Atg4c^{em2(IMPC)Marc}	homozygote	Early adult	2.91x10^-8
increased heart weight	1 supporting dataset	Atg4c^{em2(IMPC)Marc}	homozygote	Early adult	2.74x10^-5
abnormal bone structure	1 supporting dataset	Atg4c^{em2(IMPC)Marc}	homozygote	Early adult	9.94x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Atg4c.

Associated images

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Histopathology

There is no histopathology data found for Atg4c.

IMPC related publications

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External links

No external links available for Atg4c.

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*Atg4c^{em2(IMPC)Marc}*	Deletion	‌	mouse
*Atg4c^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Atg4c^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Atg4c^{tm39125(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Atg4c^{tm39125(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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