Pde5a | phosphodiesterase 5A, cGMP-specific

GeneMGI:2651499Synonyms: PDE5A1, Pde5

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Growth/size/body region Limbs/digits/tail Liver/biliary system Skeleton

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased body length	1 supporting dataset	Pde5a^em1(IMPC)Mbp	heterozygote	Early adult	2.3x10^-5
abnormal liver morphology	1 supporting dataset	Pde5a^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal caudal vertebrae morphology	1 supporting dataset	Pde5a^em1(IMPC)Mbp	heterozygote	Early adult	1.19x10^-6
small liver	1 supporting dataset	Pde5a^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pde5a.

Associated images

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Histopathology

There is no histopathology data found for Pde5a.

IMPC related publications

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External links

No external links available for Pde5a.

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*Pde5a^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Pde5a^{tm190668(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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