Adnp2 | ADNP homeobox 2

GeneMGI:2448562Synonyms: 8430420L05Rik, Zfp508

Physiological systems

21 / 24 physiological systems tested

14 Significantly impacted by the knock-out

 Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Hematopoietic system Renal/urinary system Homeostasis/metabolism Limbs/digits/tail Nervous system Respiratory system Liver/biliary system Behavior/neurological Skeleton Mortality/aging

7 No significant impact

3 Not tested

Gene metrics:26Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased prepulse inhibition2 supporting datasetsAdnp2em3(IMPC)TcphomozygoteEarly adult1.16x10-10 
absent adrenal gland1 supporting datasetAdnp2em3(IMPC)TcpheterozygoteLate adultN/A * 
abnormal bone structure1 supporting datasetAdnp2em3(IMPC)TcphomozygoteEarly adult7.44x10-5 
short tibia1 supporting datasetAdnp2em3(IMPC)TcphomozygoteEarly adult2.67x10-11 
decreased circulating serum albumin level1 supporting datasetAdnp2em3(IMPC)TcphomozygoteEarly adult9.23x10-5 
small adrenal glands1 supporting datasetAdnp2em3(IMPC)TcpheterozygoteLate adultN/A * 
small kidney1 supporting datasetAdnp2em3(IMPC)TcpheterozygoteLate adultN/A * 
preweaning lethality, incomplete penetrance3 supporting datasetsAdnp2em3(IMPC)TcphomozygoteEarly adultN/A * 
small uterus1 supporting datasetAdnp2em3(IMPC)TcpheterozygoteLate adultN/A * 
abnormal liver morphology1 supporting datasetAdnp2em3(IMPC)TcpheterozygoteLate adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Human diseases caused by Adnp2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Adnp2em3(IMPC)TcpIndelmouse
Adnp2tm1(KOMP)MbpReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Adnp2tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Adnp2tm445498(Ifitm2_intron_L1L2_GT1_LF2A_LacZ_BetactP_neo)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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