Adnp2 | ADNP homeobox 2
Physiological systems
21 / 24 physiological systems tested
14 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Hematopoietic system Renal/urinary system Homeostasis/metabolism Limbs/digits/tail Nervous system Respiratory system Liver/biliary system Behavior/neurological Skeleton Mortality/aging
7 No significant impact
3 Not tested
Data collections
Gene metrics:26Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
decreased prepulse inhibition | 2 supporting datasets | Adnp2em3(IMPC)Tcp | homozygote | Early adult | 1.16x10-10 | ||
absent adrenal gland | 1 supporting dataset | Adnp2em3(IMPC)Tcp | heterozygote | Late adult | N/A * | ||
abnormal bone structure | 1 supporting dataset | Adnp2em3(IMPC)Tcp | homozygote | Early adult | 7.44x10-5 | ||
short tibia | 1 supporting dataset | Adnp2em3(IMPC)Tcp | homozygote | Early adult | 2.67x10-11 | ||
decreased circulating serum albumin level | 1 supporting dataset | Adnp2em3(IMPC)Tcp | homozygote | Early adult | 9.23x10-5 | ||
small adrenal glands | 1 supporting dataset | Adnp2em3(IMPC)Tcp | heterozygote | Late adult | N/A * | ||
small kidney | 1 supporting dataset | Adnp2em3(IMPC)Tcp | heterozygote | Late adult | N/A * | ||
preweaning lethality, incomplete penetrance | 3 supporting datasets | Adnp2em3(IMPC)Tcp | homozygote | Early adult | N/A * | ||
small uterus | 1 supporting dataset | Adnp2em3(IMPC)Tcp | heterozygote | Late adult | N/A * | ||
abnormal liver morphology | 1 supporting dataset | Adnp2em3(IMPC)Tcp | heterozygote | Late adult | N/A * |
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Human diseases caused by Adnp2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Adnp2.
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Adnp2em3(IMPC)Tcp | Indel | | mouse |
Adnp2tm1(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
Adnp2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
Adnp2tm445498(Ifitm2_intron_L1L2_GT1_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |