Fancd2 | Fanconi anemia, complementation group D2
Physiological systems
21 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Behavior/neurological Cardiovascular system Mortality/aging Renal/urinary system
15 No significant impact
3 Not tested
Data collections
Gene metrics:11Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating iron level | 1 supporting dataset | Fancd2em1(IMPC)Hmgu | heterozygote | Early adult | 5.08x10-5 | ||
| decreased locomotor activity | 1 supporting dataset | Fancd2em1(IMPC)Hmgu | heterozygote | Early adult | 1.49x10-5 | ||
| small kidney | 1 supporting dataset | Fancd2em1(IMPC)Hmgu | heterozygote | Early adult | N/A * | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Fancd2em1(IMPC)Hmgu | heterozygote | Early adult | 1.17x10-6 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Fancd2em1(IMPC)Hmgu | heterozygote | Early adult | 9.87x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Fancd2em1(IMPC)Hmgu | homozygote | Early adult | N/A * |
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Human diseases caused by Fancd2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Fancd2.
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| Fancd2em1(IMPC)Hmgu | Exon Deletion | | mouse |
| Fancd2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Fancd2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Fancd2tm43555(L1L2_gt2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |