Dnd1 | DND microRNA-mediated repression inhibitor 1

GeneMGI:2447763Synonyms: Ter, RBMS4

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Reproductive system Adipose tissue Growth/size/body region Vision/eye Behavior/neurological Skeleton Cardiovascular system

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal retina outer nuclear layer morphology	1 supporting dataset	Dnd1^em1(IMPC)Bay	homozygote	Early adult	1.74x10^-5
male infertility	1 supporting dataset	Dnd1^em1(IMPC)Bay	homozygote	Early adult	N/A ^*
increased heart left ventricle size	1 supporting dataset	Dnd1^em1(IMPC)Bay	homozygote	Early adult	2.14x10^-5
decreased lean body mass	2 supporting datasets	Dnd1^em1(IMPC)Bay	homozygote	Early adult	5.76x10^-11
increased total body fat amount	2 supporting datasets	Dnd1^em1(IMPC)Bay	homozygote	Early adult	2.88x10^-9
female infertility	1 supporting dataset	Dnd1^em1(IMPC)Bay	homozygote	Early adult	N/A ^*
decreased bone mineral content	2 supporting datasets	Dnd1^em1(IMPC)Bay	homozygote	Early adult	2.15x10^-19
decreased bone mineral density	1 supporting dataset	Dnd1^em1(IMPC)Bay	homozygote	Early adult	3.29x10^-19
abnormal retina vasculature morphology	1 supporting dataset	Dnd1^em1(IMPC)Bay	homozygote	Early adult	1.34x10^-5
decreased grip strength	1 supporting dataset	Dnd1^em1(IMPC)Bay	homozygote	Early adult	8.5x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dnd1.

Associated images

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Histopathology

There is no histopathology data found for Dnd1.

IMPC related publications

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External links

No external links available for Dnd1.

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*Dnd1^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Dnd1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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