Galnt18 | polypeptide N-acetylgalactosaminyltransferase 18
Physiological systems
18 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system
13 No significant impact
6 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased circulating fructosamine level | 1 supporting dataset | Galnt18tm1b(KOMP)Wtsi | homozygote | Early adult | 7.66x10-6 | ||
| increased lean body mass | 1 supporting dataset | Galnt18tm1b(KOMP)Wtsi | homozygote | Early adult | 2.76x10-5 | ||
| decreased total body fat amount | 1 supporting dataset | Galnt18tm1b(KOMP)Wtsi | homozygote | Early adult | 5.87x10-5 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Galnt18tm1b(KOMP)Wtsi | homozygote | Early adult | 3.65x10-7 | ||
| increased red blood cell distribution width | 1 supporting dataset | Galnt18tm1b(KOMP)Wtsi | homozygote | Early adult | 2.37x10-8 | ||
| increased NK cell number | 1 supporting dataset | Galnt18tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/1) | 0% (0/173) |
| bone | heterozygote | n/a | 50% (1/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Galnt18 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Galnt18.
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| Galnt18tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Galnt18tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Galnt18tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |