Plac8 | placenta-specific 8
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Integument Vision/eye Cardiovascular system
16 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| cataract | 1 supporting dataset | Plac8tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.19x10-10 | ||
| abnormal vitreous body morphology | 1 supporting dataset | Plac8tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.61x10-5 | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Plac8tm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.34x10-6 | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Plac8tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.5x10-6 | ||
| abnormal retina morphology | 1 supporting dataset | Plac8tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.31x10-6 | ||
| abnormal coat appearance | 1 supporting dataset | Plac8tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.07x10-5 | ||
| abnormal lens morphology | 1 supporting dataset | Plac8tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.58x10-11 |
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Human diseases caused by Plac8 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Plac8.
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| Plac8tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Plac8tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Plac8tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Plac8tm44611(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |