Plac8 | placenta-specific 8

GeneMGI:2445289Synonyms: C15, D5Wsu111e, +1 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Integument Vision/eye Cardiovascular system

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

cataract1 supporting datasetPlac8tm1b(EUCOMM)HmguhomozygoteEarly adult3.19x10-10 
abnormal vitreous body morphology1 supporting datasetPlac8tm1b(EUCOMM)HmguhomozygoteEarly adult1.61x10-5 
persistence of hyaloid vascular system1 supporting datasetPlac8tm1b(EUCOMM)HmguhomozygoteEarly adult8.34x10-6 
abnormal retina vasculature morphology1 supporting datasetPlac8tm1b(EUCOMM)HmguhomozygoteEarly adult3.5x10-6 
abnormal retina morphology1 supporting datasetPlac8tm1b(EUCOMM)HmguhomozygoteEarly adult1.31x10-6 
abnormal coat appearance1 supporting datasetPlac8tm1b(EUCOMM)HmguhomozygoteEarly adult3.07x10-5 
abnormal lens morphology1 supporting datasetPlac8tm1b(EUCOMM)HmguhomozygoteEarly adult1.58x10-11 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Plac8tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Plac8tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Plac8tm1e(EUCOMM)HmguTargeted, non-conditional allelees cell
Plac8tm44611(L1L2_gt1)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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