Pik3c3 | phosphatidylinositol 3-kinase catalytic subunit type 3

GeneMGI:2445019Synonyms: Vps34, 5330434F23Rik

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Behavior/neurological Mortality/aging

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, incomplete penetrance	1 supporting dataset	Pik3c3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal tail movements	1 supporting dataset	Pik3c3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	7.04x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Pik3c3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased grip strength	1 supporting dataset	Pik3c3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	5.22x10^-6
decreased circulating triglyceride level	1 supporting dataset	Pik3c3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.9x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pik3c3.

Associated images

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Histopathology

There is no histopathology data found for Pik3c3.

IMPC related publications

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External links

No external links available for Pik3c3.

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*Pik3c3^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pik3c3^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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