Chd7 | chromodomain helicase DNA binding protein 7

GeneMGI:2444748Synonyms: Cycn, Obt, +13 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Behavior/neurological Mortality/aging

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:4Significant phenotypes
6Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance1 supporting datasetChd7tm2a(EUCOMM)WtsihomozygoteEarly adultN/A * 
decreased body weight2 supporting datasetsChd7WhiheterozygoteEarly adult9.01x10-6 
increased circulating glucose level1 supporting datasetChd7WhiheterozygoteEarly adult9.76x10-5 
abnormal locomotor activation1 supporting datasetChd7WhiheterozygoteEarly adult1.91x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Order Mouse and ES Cells

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Chd7WhiReporter-tagged deletion allele (with selection cassette)ES Cell
Chd7tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Chd7tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell
Chd7tm2a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Chd7tm2e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell
Chd7tm35837(L1L2_gt0)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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